de Roda Husman A M, Schuitemaker H
Dept of Clinical Viro-Immunology, University of Amsterdam, The Netherlands.
Trends Microbiol. 1998 Jun;6(6):244-9. doi: 10.1016/s0966-842x(98)01249-9.
For several years, the cellular basis behind the differences in HIV-1 tropism and the species specificity of HIV-1 has remained unclear. Since the discovery that chemokine receptors are essential cofactors for entry of HIV-1 into cells, tremendous progress has been made in the understanding of the role played by co-receptors in HIV-1 biological variability, HIV-1 transmission and AIDS pathogenesis.
多年来，HIV-1嗜性差异及HIV-1物种特异性背后的细胞基础一直不明。自从发现趋化因子受体是HIV-1进入细胞所必需的辅助因子以来，在理解辅助受体在HIV-1生物学变异性、HIV-1传播及艾滋病发病机制中所起的作用方面已取得了巨大进展。
