Kristiansen T B, Knudsen T B, Eugen-Olsen J
Department of Infectious Diseases, Copenhagen University Hospitals, Hvidovre, Denmark.
Scand J Immunol. 1998 Oct;48(4):339-46. doi: 10.1046/j.1365-3083.1998.00438.x.
Within the last three years, major progress in the understanding of acquired immune deficiency syndrome pathogenesis has been achieved. The discovery that human immunodeficiency virus (HIV), in addition to the CD4 receptor, requires the presence of a coreceptor in order to infect cells has led to a series of breakthroughs in HIV research and knowledge. These include an increased understanding of viral entry, a connection of viral phenotype to specific coreceptor use, and an unequivocal linkage of a single human gene to host susceptibility. All in all these achievements provide a number of promising new strategies for combating HIV.
在过去三年里，人们对获得性免疫缺陷综合征发病机制的理解取得了重大进展。人类免疫缺陷病毒（HIV）除了需要CD4受体外，还需要一种共受体才能感染细胞，这一发现引发了HIV研究和知识方面的一系列突破。这些突破包括对病毒进入过程的进一步了解、病毒表型与特定共受体使用之间的联系，以及明确将单个人类基因与宿主易感性联系起来。总的来说，这些成果为抗击HIV提供了一些充满希望的新策略。
