Chan T Y
Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital.
Singapore Med J. 1998 Apr;39(4):186-8.
Severe hypoglycaemia due to anti-diabetic drugs is a more important cause of medical admissions in Hong Kong (1.5%) than in Singapore (0.4%-0.8%), although the prevalence and pattern of diabetes mellitus in the two Chinese populations are similar. Review of the available drug utilisation data indicated that glibenclamide and tolbutamide are the most frequently used sulphonylurea in Hong Kong and Singapore, respectively. These drugs also predominate among diabetic patients admitted with hypoglycaemia in the respective population. Since the risk of hypoglycaemia is greater for glibenclamide than other sulphonylureas, the increased incidence of anti-diabetic drug-induced hypoglycaemia in Hong Kong may, at least in part, be related to the frequent use of glibenclamide.
尽管香港和新加坡这两个华人种群中糖尿病的患病率和模式相似，但在香港，因抗糖尿病药物导致的严重低血糖是住院治疗更为重要的原因（占1.5%），高于新加坡（占0.4%-0.8%）。对现有药物使用数据的回顾表明，格列本脲和甲苯磺丁脲分别是香港和新加坡最常使用的磺脲类药物。在各自人群中因低血糖入院的糖尿病患者中，这些药物也占主导地位。由于格列本脲导致低血糖的风险高于其他磺脲类药物，香港抗糖尿病药物所致低血糖发病率的增加可能至少部分与格列本脲的频繁使用有关。
