Chan T Y
Division of Clinical Pharmacology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.
Pharmacoepidemiol Drug Saf. 1998 Nov;7(6):411-4. doi: 10.1002/(SICI)1099-1557(199811/12)7:6<411::AID-PDS379>3.0.CO;2-U.
In order to estimate the incidence of severe hypoglycaemia (defined as episodes severe enough to require hospitalization in general medical wards) among known diabetics in Hong Kong in 1990, both the total number of such admissions to the Prince of Wales Hospital and the age and sex distribution and number of known diabetics among its catchment population were defined. The latter was derived from the 1991 census and two studies or the prevalence of diabetes mellitus in Chinese subjects in the New Territories East region in 1987 and 1990. The incidence of severe hypoglycaemia was generally higher in women than in men and in older than in younger subjects. The incidence was 15-19 times higher in subjects aged >or=60 years than in those aged <or=59 years (men 3.51 versus 0.17%, women 6.86 versus 0.43%, overall 5.16 versus 0.29%). As many as 24.16% of the subjects aged 70-74 years had severe hypoglycaemia in 1990. The overall incidence of severe hypoglycaemia in all known diabetics was 1.40%. Based on the data from a drug utilization study (70.24% and 5.93% of diabetics receiving sulphonylureas and insulins, respectively), it could be estimated that in 1990, the incidence of hypoglycaemia requiring hospitalization in general medical wards was 1.42% for sulphonylureas and 6.84% for insulins.
为了估算1990年香港已知糖尿病患者中严重低血糖症（定义为严重到需要入住普通内科病房的发作）的发病率，界定了威尔士亲王医院此类住院患者的总数以及其服务人群中已知糖尿病患者的年龄、性别分布和数量。后者来源于1991年人口普查以及1987年和1990年两项关于新界东地区中国人群糖尿病患病率的研究。严重低血糖症的发病率一般女性高于男性，年长者高于年轻者。年龄≥60岁的患者发病率比年龄≤59岁的患者高15 - 19倍（男性为3.51%对0.17%，女性为6.86%对0.43%，总体为5.16%对0.29%）。1990年，70 - 74岁的患者中多达24.16%发生了严重低血糖症。所有已知糖尿病患者中严重低血糖症的总体发病率为1.40%。根据一项药物使用研究的数据（分别有70.24%和5.93%的糖尿病患者接受磺脲类药物和胰岛素治疗），可以估算出1990年，普通内科病房中因低血糖症需要住院治疗的发病率，磺脲类药物为1.42%，胰岛素为6.84%。
