Getova D, Bowery N G
Department of Pharmacology and Toxicology, High School of Medicine and Dentistry, Plovdiv, Bulgaria.
Psychopharmacology (Berl). 1998 Jun;137(4):369-73. doi: 10.1007/s002130050632.
It has been reported that selective GABA(B) receptor antagonists can enhance cognitive performance in a variety of learning paradigms. This prompted us to examine the effects of some more potent and newly synthesised GABAB antagonists CGP 71982, CGP 62349 and CGP 55845A in an active avoidance test in rats. A two-way active avoidance test with negative reinforcement was performed for the first 5 of 12 days of antagonist administration. CGP 71982 and CGP 55845A at all doses applied (0.01-1.0 mg/kg) had an improving effect on learning, and memory retention on day 12; the rats made more avoidances in both sessions compared to controls. CGP 62349 was only active at the lowest dose tested (0.01 mg/kg). The present study confirms that GABA(B) receptor antagonists can enhance cognitive performance but provides no insight into the mechanism of action of these novel antagonists.
据报道，选择性GABA(B)受体拮抗剂可在多种学习范式中提高认知能力。这促使我们在大鼠的主动回避试验中研究一些更有效且新合成的GABAB拮抗剂CGP 71982、CGP 62349和CGP 55845A的作用。在给予拮抗剂的12天中的前5天进行了带有负强化的双向主动回避试验。所有应用剂量（0.01 - 1.0毫克/千克）的CGP 71982和CGP 55845A对第12天的学习和记忆保持有改善作用；与对照组相比，大鼠在两个试验阶段都做出了更多的回避动作。CGP 62349仅在测试的最低剂量（0.01毫克/千克）时有活性。本研究证实GABA(B)受体拮抗剂可提高认知能力，但未深入了解这些新型拮抗剂的作用机制。
