Bao S, Chen L, Thompson R F
Neuroscience Program, University of Southern California, Los Angeles 90089-2520, USA.
Behav Neurosci. 1998 Jun;112(3):714-8. doi: 10.1037//0735-7044.112.3.714.
Conditioned eyeblink responses (CRs), sensitization, and spontaneous eyeblinks were studied in C57BL/6J and BALB/c mice. Both strains of mice acquired CRs during 10 days of classical delay eyeblink conditioning. The BALB/c mice reached a higher asymptotic CR level than the C57BL/6J mice. The CRs were extinguished and recovered in both strains following conditioned stimulus-alone and paired conditioned stimulus-unconditioned stimulus training. During 10 days of explicitly unpaired training, the control groups showed no signs of sensitization and low incidence of spontaneous eyeblinks. When switched to paired training, the unpaired groups exhibited significant conditioned inhibition. These results suggest that strain differences must be considered in experimental design and data interpretation for these basic aspects of associative learning and memory.
在C57BL/6J和BALB/c小鼠中研究了条件性眨眼反应（CRs）、敏感化和自发性眨眼。两种品系的小鼠在10天的经典延迟眨眼条件反射训练中都获得了CRs。BALB/c小鼠达到的渐近CR水平高于C57BL/6J小鼠。在单独条件刺激和配对条件刺激-非条件刺激训练后，两种品系的CRs都出现消退和恢复。在10天的明确非配对训练期间，对照组没有表现出敏感化迹象，自发性眨眼发生率较低。当转换为配对训练时，非配对组表现出显著的条件性抑制。这些结果表明，在这些联想学习和记忆的基本方面的实验设计和数据解释中，必须考虑品系差异。
