来自拟荚蒾状鲁氏木的三萜类化合物和皂苷。

Triterpenes and saponins from Rudgea viburnioides.

作者信息

Young M C, Araújo A R, da Silva C A, Lopes M N, Trevisan L M, Bolzani V S

机构信息

Seção de Fisiologia e Bioquímica de Plantas, Instituto de Botânica, CP. 4005, 01061-970, São Paulo, SP, Brazil.

出版信息

J Nat Prod. 1998 Jul;61(7):936-8. doi: 10.1021/np9704617.

DOI:10.1021/np9704617

PMID:9677278

Abstract

A novel triterpene, viburgenin (1), has been isolated from an extract of the ripe fruit rinds of Rudgea viburnioides, together with the known saponins, arjunglucoside I and trachelosperosides B-1 and E-1, and the triterpenes trachelosperogenin B (2) and arjungenin. Compound 2 was previously obtained as a product from enzymatic hydrolysis, and it is reported for the first time as a natural product. The structure of compound 1 was determined as 2alpha,3beta, 19alpha,23,24-pentahydroxyurs-12-ene by extensive use of 1D and 2D NMR spectroscopic methods. Compound 1 exhibited moderate antifungal activity against Cladosporium cladosporioides.

摘要

从拟荚蒾鲁德氏木成熟果皮提取物中分离出一种新型三萜类化合物——荚蒾苷元（1），同时还分离出已知的皂苷类化合物阿琼葡萄糖苷I、络石苷B - 1和E - 1，以及三萜类化合物络石皂苷元B（2）和阿琼皂苷元。化合物2之前是通过酶促水解得到的产物，此次作为天然产物首次被报道。通过广泛使用一维和二维核磁共振光谱方法，确定化合物1的结构为2α,3β,19α,23,24 - 五羟基乌苏 - 12 - 烯。化合物1对枝孢霉表现出中等抗真菌活性。