来自短柱菝葜的甾体皂苷及其抗真菌活性。

Steroidal saponins from Smilax medica and their antifungal activity.

作者信息

Sautour Marc, Miyamoto Tomofumi, Lacaille-Dubois Marie-Aleth

机构信息

Laboratoire de Pharmacognosie, Unité de Molécules d'Intérêt Biologique, UMIB UPRES-EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 Boulevard Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.

出版信息

J Nat Prod. 2005 Oct;68(10):1489-93. doi: 10.1021/np058060b.

DOI:10.1021/np058060b

PMID:16252913

Abstract

Three new steroidal saponins (1-3) were isolated from the roots of Smilax medica, together with the known disporoside A (4). The structures of the new compounds were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR, FABMS, and HRESIMS). Compounds 1, 2, and 4 demonstrated weak antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata, and C.tropicalis, with MIC values between 12.5 and 50 microg/mL.

摘要

从短柱菝葜根中分离出三种新的甾体皂苷（1-3）以及已知的二孢皂苷A（4）。新化合物的结构主要通过广泛的光谱分析（一维和二维核磁共振、快原子轰击质谱和高分辨电喷雾电离质谱）来阐明。化合物1、2和4对人类致病酵母白色念珠菌、光滑念珠菌和热带念珠菌表现出微弱的抗真菌活性，最低抑菌浓度值在12.5至50微克/毫升之间。