一种来自南非裸鳃亚目动物海角多彩海牛和一种网角海绵纲海绵的新型呋喃倍半萜。

A new furanosesterterpene from the South African nudibranch Hypselodoris capensis and a dictyoceratida sponge.

作者信息

McPhail K, Davies-Coleman M T, Coetzee P

机构信息

Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa, and Zoology Department, University of Port Elizabeth, Port Elizabeth, South Africa.

出版信息

J Nat Prod. 1998 Jul;61(7):961-4. doi: 10.1021/np980051y.

DOI:10.1021/np980051y

PMID:9677286

Abstract

The known cytotoxic, linear beta-substituted sesterterpenes (18R)-variabilin (1) and 22-deoxyvariabilin (4) and a new variant, 22-deoxy-23-hydroxymethylvariabilin (5), were isolated from the endemic South African nudibranch Hypselodoris capensis together with the known ichthyotoxic sesquiterpenes nakafuran-8 (2) and -9 (3). One of H. capensis' dietary sponges, a Fasciospongia sp. collected simultaneously with the nudibranchs, yielded sesterterpenes 1, 4, and 5 and the ubiquitous prenylated furan derivative, furospinosulin-1 (7).

摘要

从南非特有的裸鳃亚目动物海角多彩海牛（Hypselodoris capensis）中分离出了已知具有细胞毒性的线性β-取代的倍半萜烯（18R）-变叶海牛素（1）和22-脱氧变叶海牛素（4）以及一种新的变体22-脱氧-23-羟甲基变叶海牛素（5），同时还分离出了已知具有鱼毒性的倍半萜烯中呋喃-8（2）和中呋喃-9（3）。海角多彩海牛的一种食源海绵，一种与裸鳃亚目动物同时采集的Fasciospongia属海绵，产生了倍半萜烯1、4和5以及普遍存在的异戊烯基化呋喃衍生物呋喃棘霉素-1（7）。