Desarnaulds A B, Borruat F X, Herbort C P, de Courten C
Hôpital Ophtalmique Jules Gonin, Lausanne.
Klin Monbl Augenheilkd. 1998 May;212(5):318-20.
Multiple evanescent white dot syndrome (MEWDS) is a benign acquired chorioretinal disorder occurring mostly in young adults. Its pathophysiology is unknown. To describe the results of indocyanine green angiography (ICGA) in MEWDS.
Four patients with MEWDS were investigated by ICGA.
In all cases, ICGA revealed numerous choroidal hypofluorescent lesions that largely outnumbered the lesions visible with either fundoscopy or fluorescein angiography. Three cases showed a blind spot enlargement on perimetry associated with the presence of a large peripapillary hypofluorescent zone on ICGA. Three cases showed macular granularity on fundoscopy correlating with a significant subfoveal hypfluorescent lesion on ICGA. Evolution was always favorable with disappearance of the hypofluorescent choroidal lesions.
Our results confirm that MEWDS is primarily a choroidal disorder. The blind spot enlargement and the macular granularity, frequently detected in MEWDS, result from larger peripapillary and subfoveal choroidal lesions.
多发性一过性白点综合征（MEWDS）是一种主要发生于年轻人的良性获得性脉络膜视网膜疾病。其病理生理学尚不清楚。描述吲哚菁绿血管造影（ICGA）在MEWDS中的检查结果。
对4例MEWDS患者进行了ICGA检查。
在所有病例中，ICGA均显示大量脉络膜低荧光病变，其数量远远超过检眼镜或荧光素血管造影可见的病变。3例患者在视野检查中出现盲点扩大，ICGA显示视乳头周围存在大的低荧光区。3例患者检眼镜检查显示黄斑区颗粒状改变，与ICGA上黄斑中心凹下明显的低荧光病变相关。随着脉络膜低荧光病变的消失，病情总是向好的方向发展。
我们的结果证实MEWDS主要是一种脉络膜疾病。MEWDS中经常检测到盲点扩大和黄斑区颗粒状改变，是由视乳头周围和黄斑中心凹下较大的脉络膜病变引起的。
