Oymar K, Bjerknes R
Department of Pediatrics, Rogaland County Hospital, Stavanger, Norway.
Pediatr Allergy Immunol. 1998 May;9(2):73-9. doi: 10.1111/j.1399-3038.1998.tb00307.x.
The object of the study was to assess the levels of circulating forms of the cellular adhesion molecules ICAM-1, VCAM-1, E-selectin, L-selectin and P-selectin in young children with asthma and acute bronchiolitis. Thirty-nine children aged 12 to 84 months with mild or moderate asthma were studied at admission for acute asthma (n = 15) or in a stable phase (n = 24). Ten of the children with acute asthma were seen again after one month. Twenty-two children aged 1 to 17 months with acute bronchiolitis and nine non-atopic controls were also included in the study. In children with acute asthma, the mean concentration of circulating soluble ICAM-1 (sICAM-1) was increased compared to children with stable asthma (mean 442 micrograms/l versus 363 micrograms/l; p < 0.001) and to controls (363 micrograms/l; p < 0.05). The levels of sICAM-1 remained high at follow up. In children with stable asthma, the mean serum concentration of soluble L-selectin (sL-selectin) (2080 micrograms) was significantly higher than in the controls (1664 micrograms/l; p < 0.05). The levels of circulating cellular adhesion molecules were similar in atopic and non-atopic asthmatics. Children with acute bronchiolitis had increased serum levels of soluble VCAM-1 (sVCAM-1) (1637 micrograms/l versus 1019 micrograms/l in the controls; p < 0.01) and sL-selectin (2041 micrograms/l versus 1664 micrograms/l in the controls; p < 0.05). There was no difference between the levels of circulating cellular adhesion molecules in children with respiratory syncytial virus (RSV) positive and RSV negative bronchiolitis. Soluble E-selectin (sE-selectin) and soluble P-selectin (sP-selectin) in serum were not significantly increased in any of the groups studied. In conclusion, our data suggest differential patterns of circulating cellular adhesion molecules in young children with acute asthma, stable asthma, and acute bronchiolitis, which may reflect differences in the underlying inflammatory processes in these obstructive pulmonary diseases.
本研究的目的是评估哮喘和急性细支气管炎幼儿体内细胞黏附分子ICAM - 1、VCAM - 1、E - 选择素、L - 选择素和P - 选择素循环形式的水平。对39名年龄在12至84个月的轻度或中度哮喘儿童进行了研究，其中15名急性哮喘患儿在入院时接受研究，24名处于稳定期的哮喘患儿也参与研究。10名急性哮喘患儿在1个月后再次接受观察。研究还纳入了22名年龄在1至17个月的急性细支气管炎患儿和9名非特应性对照儿童。在急性哮喘患儿中，循环可溶性ICAM - 1（sICAM - 1）的平均浓度相较于稳定期哮喘患儿（分别为442微克/升和363微克/升；p < 0.001）以及对照儿童（363微克/升；p < 0.05）有所升高。随访时sICAM - 1水平仍维持在高位。在稳定期哮喘患儿中，可溶性L - 选择素（sL - 选择素）的平均血清浓度（2080微克）显著高于对照儿童（1664微克/升；p < 0.05）。特应性和非特应性哮喘患儿循环细胞黏附分子水平相似。急性细支气管炎患儿血清中可溶性VCAM - 1（sVCAM - 1）水平升高（对照儿童为1019微克/升，患儿为1637微克/升；p < 0.01），sL - 选择素水平也升高（对照儿童为1664微克/升，患儿为2041微克/升；p < 0.05）。呼吸道合胞病毒（RSV）阳性和RSV阴性细支气管炎患儿的循环细胞黏附分子水平无差异。研究的任何组中血清可溶性E - 选择素（sE - 选择素）和可溶性P - 选择素（sP - 选择素）均未显著升高。总之，我们的数据表明，急性哮喘、稳定期哮喘和急性细支气管炎幼儿体内循环细胞黏附分子呈现不同模式，这可能反映了这些阻塞性肺部疾病潜在炎症过程的差异。
