Jirecek S, Kink E, Wenzl R, Vytiska-Binsdorfer E, Huber J
Abteilung für Gynäkologische Endokrinologie und Sterilitätsbehandlung, Universitätsklinik für Frauenheilkunde, Wien, Osterreich.
Wien Klin Wochenschr. 1998 Jun 26;110(12):441-5.
Over a 12-month period we evaluated 185 patients who consulted our outpatient department with symptoms of secondary amenorrhoea. Hormonal levels and body mass index were determined and an assessment made, on the basis of specific questioning. of the occurrence of possible mental alterations in the patients before they became amenorrhoic. Of our collective, 36 patients (19.5%) showed normal hormonal values, 50 patients (26%) were hypoestrogenemic, 46 women (25%) had elevated androgens, 15 patients (8%) had increased gonadotropins, 4 patients (2%) suffered from hyperprolactinemia, and 2 women (1%) had thyroid dysfunction. The remaining 32 amenorrhoic patients (17.2%) demonstrated different combinations of altered hormone values. The hypoestrogenemic patients showed a significant difference (p < 0.043) in body mass index in comparison with patients demonstrating normal hormone values. In contrast to reports in the literature hypoestrogenemia was the most frequent cause of secondary amenorrhoea in our study.
在12个月的时间里，我们对185名因继发性闭经症状前来我院门诊就诊的患者进行了评估。测定了她们的激素水平和体重指数，并通过特定询问对患者闭经前可能出现的精神变化情况进行了评估。在我们的研究对象中，36名患者（19.5%）激素值正常，50名患者（26%）雌激素水平低下，46名女性（25%）雄激素升高，15名患者（8%）促性腺激素升高，4名患者（2%）患有高泌乳素血症，2名女性（1%）存在甲状腺功能障碍。其余32名闭经患者（17.2%）表现出激素值改变的不同组合。与激素值正常的患者相比，雌激素水平低下的患者体重指数存在显著差异（p < 0.043）。与文献报道相反，在我们的研究中，雌激素水平低下是继发性闭经最常见的原因。
