Eriksen N L, Helfgott A W
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Health Science Center-Houston, LBJ Hospital 77026, USA.
Infect Dis Obstet Gynecol. 1998;6(1):13-7. doi: 10.1002/(SICI)1098-0997(1998)6:1<13::AID-IDOG4>3.0.CO;2-8.
To determine the prevalence of cutaneous anergy in pregnant and nonpregnant women who are seropositive for human immunodeficiency virus.
The medical records of 159 women seropositive for human immunodeficiency virus were reviewed. Demographic characteristics and tuberculin skin test results were abstracted from the chart. Tuberculin skin testing was performed by the Mantoux method (5 tuberculin units of purified protein derivative injected intradermally). Anergy testing was performed using any two of the three following antigens; tetanus toxoid, mumps, or Candida skin test antigen. A positive tuberculin test was defined as induration of 5 mm or more, and a positive test for the other antigens was defined as any amount of induration over the skin test area. Anergy was defined as any amount of induration to the other antigens. A CD4+T lymphocyte count was obtained at the time of skin testing. Continuous variables were analyzed using the Mann Whitney-U test. Categorical data were analyzed with the chi-square or Fisher's exact test as appropriate. A two-tailed P value < 0.05 was considered significant.
There were 102 nonpregnant and 57 pregnant women who returned to have their skin test results read. There was no significant difference in the prevalence of positive, negative or anergic skin test results between groups. The CD4+T lymphocyte count (mean +/- standard deviation) in patients with anergic results was similar between pregnant (375 +/- 256/mm3) and nonpregnant (358 +/- 305/mm3) women (P = 0.64).
The prevalence of cutaneous anergy is similar among pregnant and nonpregnant women seropositive for human immunodeficiency virus.
确定人类免疫缺陷病毒血清学阳性的孕妇和非孕妇中皮肤无反应性的患病率。
回顾了159例人类免疫缺陷病毒血清学阳性女性的病历。从病历中提取人口统计学特征和结核菌素皮肤试验结果。采用曼托试验法（皮内注射5个结核菌素单位的纯化蛋白衍生物）进行结核菌素皮肤试验。使用以下三种抗原中的任意两种进行无反应性检测：破伤风类毒素、腮腺炎或念珠菌皮肤试验抗原。结核菌素试验阳性定义为硬结直径5mm或更大，其他抗原试验阳性定义为皮肤试验区域出现任何硬结。无反应性定义为对其他抗原出现任何硬结。在皮肤试验时获取CD4+T淋巴细胞计数。连续变量采用曼-惠特尼U检验进行分析。分类数据根据情况采用卡方检验或费舍尔精确检验进行分析。双侧P值<0.05被认为具有统计学意义。
102例非孕妇和57例孕妇返回读取皮肤试验结果。两组之间阳性、阴性或无反应性皮肤试验结果的患病率无显著差异。无反应性结果患者的CD4+T淋巴细胞计数（平均值±标准差）在孕妇（375±256/mm³）和非孕妇（358±305/mm³）之间相似（P=0.64）。
人类免疫缺陷病毒血清学阳性的孕妇和非孕妇中皮肤无反应性的患病率相似。
