Toyozaki T, Hiroe M, Tanaka M, Nagata S, Ohwada H, Marumo F
Division of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Japan.
Am J Cardiol. 1998 Jul 15;82(2):246-8. doi: 10.1016/s0002-9149(98)00300-2.
Serum levels of soluble Fas ligand (sFasL) increased with the severity of congestive heart failure (p <0.01), and the percentages of apoptotic myocytes detected by in situ DNA nick-end labeling were significantly higher in the patients with increased levels of sFasL than in those with normal levels of sFasL (p <0.05). These findings indicated that sFasL may play an important role in pathogenesis of myocarditis.
可溶性Fas配体（sFasL）的血清水平随充血性心力衰竭的严重程度增加而升高（p<0.01），并且通过原位DNA缺口末端标记检测到的凋亡心肌细胞百分比在sFasL水平升高的患者中显著高于sFasL水平正常的患者（p<0.05）。这些发现表明sFasL可能在心肌炎的发病机制中起重要作用。
