Bozzola M, De Amici M, Zecca M, Schimpff R M, Rapaport R
Department of Paediatrics, University of Pavia, Italy.
Eur J Endocrinol. 1998 Jun;138(6):640-3. doi: 10.1530/eje.0.1380640.
We measured serum tumour necrosis factor-alpha (TNF-alpha) as well as interleukin-1betta (IL-1beta) and GH concentrations in 15 children with isolated growth hormone deficiency (GHD), age range 5.1-13.9 years, before and 4 and 24h after the first GH injection (0.1 IU/kg s.c.). No differences were found in basal concentrations of serum TNF-alpha and IL-1beta between GHD children (10.01 +/- 1.55 pg/ml and 2.14 +/- .16 ng/ml respectively) and sex- and age-matched controls (11.57 +/- 2.16 pg/ml and 3.78 +/- 1.46 ng/ml respectively). In GHD children, serum TNF-alpha and IL-1beta values had significantly increased (P < 0.002) 4h (26.75 +/- 5.57 pg/ml and 2.99 +/- 0.21 ng/ml respectively) and decreased again 24 h after GH administration. Likewise, serum GH levels had significantly increased 4 h (from 1.29 +/- 0.69 to 48.71 +/- 13.35 ng/ml, P < 0.001) and decreased to basal values 24h after GH administration. A significant correlation was found between basal serum concentrations of GH and those of both TNF-alpha (P < 0.01) and IL-1beta (P < 0.05). However, no correlation was found between serum GH concentration and either TNF-alpha or IL-1beta levels 4 and 24h after GH administration. Our data suggest that GH plays a role in modulating TNF-alpha and IL-1beta release in humans.
我们检测了15名孤立性生长激素缺乏症（GHD）儿童（年龄范围5.1 - 13.9岁）在首次皮下注射生长激素（0.1 IU/kg）前、注射后4小时和24小时的血清肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）以及生长激素（GH）浓度。GHD儿童（血清TNF-α和IL-1β的基础浓度分别为10.01±1.55 pg/ml和2.14±0.16 ng/ml）与性别和年龄匹配的对照组（分别为11.57±2.16 pg/ml和3.78±1.46 ng/ml）之间，血清TNF-α和IL-1β的基础浓度未发现差异。在GHD儿童中，血清TNF-α和IL-1β值在注射生长激素后4小时显著升高（P < 0.002）（分别为26.75±5.57 pg/ml和2.99±0.21 ng/ml），并在注射后24小时再次下降。同样，血清生长激素水平在注射后4小时显著升高（从1.29±0.69升高至48.71±13.35 ng/ml，P < 0.001），并在注射后24小时降至基础值。发现基础血清生长激素浓度与TNF-α（P < 0.01）和IL-1β（P < 0.05）的浓度之间存在显著相关性。然而，在注射生长激素后4小时和24小时，血清生长激素浓度与TNF-α或IL-1β水平之间未发现相关性。我们的数据表明，生长激素在调节人体TNF-α和IL-1β释放中发挥作用。
