Cooke A R, Ward W O
Proc Soc Exp Biol Med. 1976 Sep;152(4):656-8. doi: 10.3181/00379727-152-39461.
The effects of tryptophan and its metabolites were studied to determine whether the known inhibiting effect of tryptophan on emptying was due to local or systemic effects or due to tryptophan metabolites. In five dogs with chronic gastric fistulas, instillation of 300 ml of DL-kynurenine (5mM), 5-hydroxytryptophan (mM), or 5-hydroxytryptamine (20 mM) into the gut did not slow gastric emptying. Furthermore, iv infusion of L-tryptophan (5, 20, 50 mM), DL-kynurenine (2, 5, 10 mM), 5-hydroxytryptamine (2mM, 10 mM), and 3-indolepyruvic acid (2, 5, 10 mM) also did not slow gastric emptying. These studies indicate that tryptophan slows gastric emptying by exciting a receptor in the gut and not by a direct effect on the stomach or brain or via its major metabolites.
研究了色氨酸及其代谢产物的作用，以确定色氨酸对胃排空的已知抑制作用是由于局部或全身效应，还是由于色氨酸代谢产物所致。在五只患有慢性胃瘘的狗中，向肠道内注入300毫升DL-犬尿氨酸（5毫摩尔）、5-羟色氨酸（毫摩尔）或5-羟色胺（20毫摩尔）并未减慢胃排空。此外，静脉输注L-色氨酸（5、20、50毫摩尔）、DL-犬尿氨酸（2、5、10毫摩尔）、5-羟色胺（2毫摩尔、10毫摩尔）和3-吲哚丙酮酸（2、5、10毫摩尔）也未减慢胃排空。这些研究表明，色氨酸通过刺激肠道中的一种受体来减慢胃排空，而不是直接作用于胃或大脑，也不是通过其主要代谢产物起作用。
