Milman N, Rosenstock S, Andersen L, Jørgensen T, Bonnevie O
Department of Medicine, Naestved Hospital, Naestved, Denmark.
Gastroenterology. 1998 Aug;115(2):268-74. doi: 10.1016/s0016-5085(98)70192-1.
BACKGROUND & AIMS: Helicobacter pylori infection was recently associated with iron-deficiency anemia. The aim of this study was to examine the relationship between H. pylori infection, hemoglobin, and iron status using serum ferritin as a marker for total body iron.
Serum ferritin, hemoglobin, and immunoglobulin G (IgG) antibodies against H. pylori were assessed in 2794 Danish adults who attended a population survey. IgG antibodies were measured with an in-house enzyme-linked immunosorbent assay, serum ferritin with an immunoradiometric assay, and hemoglobin with Coulter-S.
The seroprevalence of H. pylori infection did not relate to hemoglobin. Serum ferritin levels were significantly lower in men (114 vs. 120 microg/L; P = 0.01) and in postmenopausal women (63 vs. 77 microg/L; P = 0.02) who were IgG positive than in seronegative individuals. IgG-positive people more often had reduced serum ferritin levels (</=30 microg/L) than seronegative people. This association persisted in multivariate analysis after adjusting for possible confounding factors (odds ratio, 1.4; 95% confidence interval 1.1-1. 8).
Serum ferritin levels are reduced in people with increased IgG antibodies to H. pylori. H. pylori infection affects iron metabolism in humans.
幽门螺杆菌感染最近被认为与缺铁性贫血有关。本研究旨在以血清铁蛋白作为全身铁的标志物，探讨幽门螺杆菌感染、血红蛋白和铁状态之间的关系。
对参加一项人群调查的2794名丹麦成年人进行血清铁蛋白、血红蛋白和抗幽门螺杆菌免疫球蛋白G（IgG）抗体检测。IgG抗体采用内部酶联免疫吸附测定法检测，血清铁蛋白采用免疫放射测定法检测，血红蛋白采用库尔特S检测。
幽门螺杆菌感染的血清流行率与血红蛋白无关。IgG阳性的男性（114 vs. 120 μg/L；P = 0.01）和绝经后女性（63 vs. 77 μg/L；P = 0.02）的血清铁蛋白水平显著低于血清阴性个体。IgG阳性人群血清铁蛋白水平降低（≤30 μg/L）的情况比血清阴性人群更常见。在调整可能的混杂因素后，这种关联在多变量分析中仍然存在（比值比，1.4；95%置信区间1.1 - 1.8）。
抗幽门螺杆菌IgG抗体增加的人群血清铁蛋白水平降低。幽门螺杆菌感染影响人体铁代谢。
