Mubarak Nahla, Gasim Gasim I, Khalafalla Khalifa E, Ali Naj I, Adam Ishag
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Khartoum, PO Box 102, Khartoum, Sudan.
Qassim College of Medicine, Kingdom of Saudi Arabia.
Trans R Soc Trop Med Hyg. 2014 Jun;108(6):380-4. doi: 10.1093/trstmh/tru044. Epub 2014 Mar 30.
Helicobacter pylori is a common gut pathogen that is linked to many complications of pregnancy such as iron deficiency anemia, pre-eclampsia and thrombocytopenia. There are no published data on H. pylori in Sudan.
A cross-sectional study was conducted during the period May-June 2012 at the antenatal care unit of Khartoum Hospital, Sudan, to investigate prevalence of H. pylori and its association, if any, with anemia and thrombocytopenia. Obstetric and medical histories were gathered using questionnaires. Hemoglobin and serum ferritin were measured and H. pylori antibodies (IgA and IgG) investigated using ELISA.
Among 179 women, rates of positivity for specific IgG formed against H. pylori were 69.8% (125/179), 94.0% (168/179) and 5.6% (10/179) for IgA, IgG and both IgG and IgA, respectively. There was no association between the expected risk factors (age, parity, education) and H. pylori seropositivity. Of these women, 42/179 (24.3%), 50/179 (28.9%) and 19/179 (11%), respectively, were anemic (hemoglobin <11 g/dl) or had iron deficiency (serum ferritin <15 µg/l) or iron deficiency anemia. There was no association between H. pylori infection and anemia (OR=1.0, 95% CI=0.3-3.2, p=1.0), iron deficiency (OR=0.6, 95% CI=0.1-3.8, p=0.367) or thrombocytopenia (OR=2.0, 95% CI=0.4-8.4, p=0.322).
There is a high prevalence of H. pylori infection among pregnant women in Khartoum, Sudan, and it is not associated with anemia or thrombocytopenia.
幽门螺杆菌是一种常见的肠道病原体，与许多妊娠并发症有关，如缺铁性贫血、先兆子痫和血小板减少症。苏丹尚无关于幽门螺杆菌的公开数据。
2012年5月至6月期间，在苏丹喀土穆医院的产前护理病房进行了一项横断面研究，以调查幽门螺杆菌的患病率及其与贫血和血小板减少症（若有关联）的关系。通过问卷收集产科和病史。测量血红蛋白和血清铁蛋白，并使用酶联免疫吸附测定法检测幽门螺杆菌抗体（IgA和IgG）。
在179名女性中，针对幽门螺杆菌产生的特异性IgG阳性率分别为：IgA为69.8%（125/179），IgG为94.0%（168/179），IgG和IgA均为阳性为5.6%（10/179）。预期的风险因素（年龄、产次、教育程度）与幽门螺杆菌血清阳性之间无关联。在这些女性中，分别有42/179（24.3%）、50/179（28.9%）和19/179（11%）患有贫血（血红蛋白<11 g/dl）或缺铁（血清铁蛋白<15 μg/l）或缺铁性贫血。幽门螺杆菌感染与贫血（比值比=1.0，95%置信区间=0.3 - 3.2，p = 1.0）、缺铁（比值比=0.6，95%置信区间=
