Cosca P A, Smith S, Chatfield S, Meleason A, Muir C A, Nerantzis S, Petrofsky M, Williams S
National Institutes of Health, National Cancer Institute in Bethesda, MD, USA.
Oncol Nurs Forum. 1998 Jul;25(6):1073-6.
PURPOSE/OBJECTIVES: To determine if clots are present in the initial 10 ml of blood routinely discarded from venous access devices (VADs) prior to blood sampling, and to determine if clots form in the discard blood specimen during the five minutes required to complete blood specimen sampling.
A pretest/post-test design.
A large, mid-Atlantic research institution.
A convenience sample of 50 adult patients with cancer (27 males and 23 females) with a median age of 60. A large sampling size variation existed among the different VADs.
Two 5 ml discard specimens were drawn into separate syringes. Syringe #1 was filtered immediately, and syringe #2 was filtered after a five-minute dwell time. Both samples were filtered through a 40 micron filter.
The presence or absence of clots.
Fifty percent (n = 25) of the VADs had clots present on the filter from syringe #1. The clots varied in length, width, depth, and diameter, which precluded a consistent measurement. The investigators were able to measure either the diameter or length, depending on the shape of the clots. The majority of the clots (n = 17) appeared to be shaped like the lumen of a catheter and varied from 0.1 cm to 1.2 cm in length. Six clots were round and varied in diameter from 1.6 mm to 2.8 mm. Only 4% (n = 2) of the VADs had clots in syringe #2, but those clots were much larger, measuring 8.3 mm and 18.4 mm.
The study addresses concerns of the investigators regarding the clinical practice of reinfusing discard blood obtained from VADs. Whether the clots present in the catheter and their reinfusion represent a significant risk to patient outcome is unclear.
Until further research is conducted and the degree of risk can be better defined, methods of drawing blood that require reinfusion of discard blood from VADs are not recommended.
目的/目标:确定在采血前从静脉通路装置(VAD)常规丢弃的最初10毫升血液中是否存在凝块,并确定在完成血标本采集所需的五分钟内,丢弃的血标本中是否会形成凝块。
前测/后测设计。
大西洋中部的一家大型研究机构。
50例成年癌症患者(27例男性和23例女性)的便利样本,中位年龄为60岁。不同的VAD之间存在很大的样本量差异。
将两份5毫升的丢弃标本分别抽入单独的注射器中。注射器1立即过滤,注射器2在静置五分钟后过滤。两份样本均通过40微米的过滤器过滤。
凝块的有无。
50%(n = 25)的VAD在注射器1的过滤器上有凝块。凝块在长度、宽度、深度和直径上各不相同,无法进行一致的测量。研究人员能够根据凝块的形状测量其直径或长度。大多数凝块(n = 17)看起来像导管腔的形状,长度从0.1厘米到1.2厘米不等。六个凝块是圆形的,直径从1.6毫米到2.8毫米不等。只有4%(n = 2)的VAD在注射器2中有凝块,但这些凝块要大得多,尺寸为8.3毫米和18.4毫米。
该研究解决了研究人员对回输从VAD获得的丢弃血液的临床实践的担忧。导管中存在的凝块及其回输是否对患者预后构成重大风险尚不清楚。
在进行进一步研究并能更好地确定风险程度之前,不建议采用需要回输VAD丢弃血液的采血方法。