Rudy J W, Pugh C R
Department of Psychology, University of Colorado, Boulder 80309, USA.
J Exp Psychol Anim Behav Process. 1998 Jul;24(3):316-24. doi: 10.1037//0097-7403.24.3.316.
Time of conditioning influences long-term retention of contextual but not auditory-cue fear conditioning. Long-Evans rats (Rattus norvegicus) conditioned at 12 noon displayed reduced contextual fear conditioning compared to rats conditioned at 8 a.m. or 4 p.m. This effect was eliminated by exposure to the context 24 hr prior to conditioning and by a posttrial injection of corticosterone (1.0 mg/kg). Time of conditioning did not influence short-term retention of contextual fear. These results suggest that time of conditioning influences the posttrial processes that construct a memory representation of the context. They also support the view that contextual and auditory-cue fear conditioning depend on different processes. These results are discussed in relation to the concept of memory storage modulators.
条件化时间影响情境性恐惧条件反射的长期记忆，但不影响听觉线索性恐惧条件反射。与上午8点或下午4点进行条件化的Long-Evans大鼠（褐家鼠）相比，中午12点进行条件化的大鼠表现出情境性恐惧条件反射减弱。在条件化前24小时暴露于该情境以及试验后注射皮质酮（1.0毫克/千克）可消除这种效应。条件化时间不影响情境性恐惧的短期记忆。这些结果表明，条件化时间影响构建情境记忆表征的试验后过程。它们还支持情境性和听觉线索性恐惧条件反射依赖于不同过程的观点。结合记忆存储调节因子的概念对这些结果进行了讨论。
