Sármán B, Tóth M, Somogyi A
Semmelweis Medical University 2nd and 1st Internal Medicine Department, Budapest, Hungary.
Diabetes Metab Rev. 1998 Jun;14(2):171-5. doi: 10.1002/(sici)1099-0895(199806)14:2<171::aid-dmr207>3.0.co;2-g.
Endothelin-1 is mainly synthesized by the vascular endothelial cells and acts on the vascular smooth muscle. Because of its vasoconstrictor and mitogenic effects it plays a role in the development of vascular diseases. In diabetes mellitus atherosclerosis is accelerated. The authors summarize the available data of the role of endothelin-1 in Type 1 and Type 2 diabetes mellitus and the development of diabetic complication.
内皮素-1主要由血管内皮细胞合成，并作用于血管平滑肌。由于其血管收缩和促有丝分裂作用，它在血管疾病的发展中起作用。在糖尿病中，动脉粥样硬化加速。作者总结了内皮素-1在1型和2型糖尿病以及糖尿病并发症发展中作用的现有数据。
