Powell R M, Schmitt V, Ward T, Goodfellow I, Evans D J, Almond J W
School of Animal and Microbial Sciences, University of Reading, Whiteknights, UK.
J Gen Virol. 1998 Jul;79 ( Pt 7):1707-13. doi: 10.1099/0022-1317-79-7-1707.
Several echoviruses (EVs) have previously been shown to use decay accelerating factor (DAF) as a cellular receptor. Since DAF is expressed on erythrocytes, EVs that use this receptor cause haemagglutination. Here we show that all EVs that haemagglutinate do so via attachment to DAF and that this interaction can be inhibited by a monoclonal antibody (MAb) specific for DAF domain SCR3. Although the viruses haemagglutinate via DAF some can bind to rhabdomyosarcoma cells from which DAF has been removed and infect in the presence of a MAb against DAF. This suggests that some EVs have the capacity to interact with more than one cellular receptor.
先前已证明几种肠道病毒（EVs）利用衰变加速因子（DAF）作为细胞受体。由于DAF在红细胞上表达，利用该受体的EVs会引起血细胞凝集。在此我们表明，所有具有血细胞凝集作用的EVs都是通过与DAF结合来实现的，并且这种相互作用可被针对DAF结构域SCR3的单克隆抗体（MAb）抑制。尽管这些病毒通过DAF引起血细胞凝集，但有些病毒可以与已去除DAF的横纹肌肉瘤细胞结合，并在存在抗DAF单克隆抗体的情况下感染细胞。这表明一些EVs有能力与不止一种细胞受体相互作用。
