Weind K L, Maier C F, Rutt B K, Moussa M
Department of Medical Biophysics, University of Western Ontario, London, Canada.
Radiology. 1998 Aug;208(2):477-83. doi: 10.1148/radiology.208.2.9680579.
To compare spatial patterns of blood vessels between invasive breast carcinomas and fibroadenomas to improve the diagnostic specificity of noninvasive vascular magnetic resonance imaging and color Doppler ultrasound.
Nineteen invasive ductal carcinomas and 20 fibroadenomas from 39 patients were stained for factor VIII-related antigen. Vessels smaller than 40 microns were counted in x200 fields defined in peripheral and central areas of the tumor and in normal tissue adjacent to fibroadenomas. Significant differences in vessel density were determined with Student t tests and one-way analyses of variance. Distributions of vessels 40 microns or larger were qualitatively evaluated.
There were 9-105 vessels (mean, 31.4 vessels) smaller than 40 microns per x200 peripheral and 4-57 vessels (mean, 20.1 vessels) smaller than 40 microns per x200 central carcinoma field. There was no significant difference in vessel density between the two groups. Peripheral microvessel density was significantly higher (P < .01) than central microvessel density in 15 (79%) of the 19 carcinomas and in three (16%) of 19 fibroadenomas. (A Student t test could not be performed in one case of fibroadenoma; size permitted only one countable field according to the authors' criteria.) The 18 cases with normal tissue had 21-229 vessels (mean, 80.5 vessels) per field; in 16 (89%) of the 18 cases, these vessel counts were significantly higher (P < .01) than those in the fibroadenoma cases. Vessels 40 microns or larger were found mainly in the periphery of carcinomas and were more uniformly distributed in fibroadenomas.
Evaluation of the spatial distribution of vessels and the ability to resolve vessel sizes may add valuable information to the imaging-based diagnostic work-up of indeterminate solid breast lesions.
比较浸润性乳腺癌与纤维腺瘤之间血管的空间模式，以提高无创血管磁共振成像和彩色多普勒超声的诊断特异性。
对39例患者的19例浸润性导管癌和20例纤维腺瘤进行VIII因子相关抗原染色。在肿瘤周边和中央区域以及纤维腺瘤相邻的正常组织中定义的×200视野内，对直径小于40微米的血管进行计数。采用Student t检验和单因素方差分析确定血管密度的显著差异。对直径40微米及以上的血管分布进行定性评估。
每×200周边癌野中直径小于40微米的血管有9 - 105条（平均31.4条），每×200中央癌野中有4 - 57条（平均20.1条）。两组之间血管密度无显著差异。19例癌中的15例（79%）和19例纤维腺瘤中的3例（16%），周边微血管密度显著高于中央微血管密度（P <.01）。（1例纤维腺瘤因大小仅允许一个可计数视野，根据作者标准无法进行Student t检验）。18例有正常组织的病例中，每个视野有21 - 229条血管（平均80.5条）；18例中的16例（89%），这些血管计数显著高于纤维腺瘤病例（P <.01）。直径40微米及以上的血管主要见于癌的周边，在纤维腺瘤中分布更均匀。
评估血管的空间分布以及分辨血管大小的能力，可能会为基于影像学的不确定实性乳腺病变诊断检查增添有价值的信息。
