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Giant hairpins formed by CUG repeats in myotonic dystrophy messenger RNAs might sterically block RNA export through nuclear pores.

作者信息

Koch K S, Leffert H L

机构信息

Department of Pharmacology, University of California at San Diego, La Jolla 92093-0636, USA.

出版信息

J Theor Biol. 1998 Jun 21;192(4):505-14. doi: 10.1006/jtbi.1998.0679.

DOI:10.1006/jtbi.1998.0679
PMID:9680723
Abstract

Energy minimization calculations were used to generate secondary structures of partial and full-length myotonic dystrophy messenger RNAs (DMPK mRNAs) carrying variable numbers of CUG triplet repeats (n = 0 to 500). The results suggest that (1) unitary hairpins are the most stable structures formed; (2) long-axis distances of unfolded hairpins are directly proportional to CUG repeat numbers; and (3) hairpins composed of CUG repeats might form interstem clusters that are stabilized by hydrogen or ionic bonds. A model is proposed whereby DMPK mRNAs are sterically impeded from transport through nuclear pores, by giant hairpins or hairpin clusters formed by CUG repeats above a limit size (n > or = 44).

摘要

相似文献

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2
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