Chan S W, Reade P C
School of Dental Science, University of Melbourne, Victoria, Australia.
Oral Dis. 1998 Jun;4(2):120-9. doi: 10.1111/j.1601-0825.1998.tb00268.x.
L-ascorbic acid is an essential dietary vitamin in humans, primates and certain mammals and is endogenously synthesised in some species. Epidemiological and ecological studies have shown that L-ascorbic acid has a protective effect against cancer, in particular non-hormone-dependent malignancies, such as oropharyngeal neoplasms. Experimental in vivo and in vitro studies, however, have yielded more controversial results, suggesting that the effects of L-ascorbic acid are dose- and perhaps, time-dependent with different effects depending on the species or organ studied. An update of the epidemiological and experimental evidence linking L-ascorbic acid to oral cancer and carcinogenesis is discussed together with a brief review of the possible mechanisms of action of L-ascorbic acid.
L-抗坏血酸是人类、灵长类动物和某些哺乳动物必需的膳食维生素，在某些物种中可内源性合成。流行病学和生态学研究表明，L-抗坏血酸对癌症具有保护作用，尤其是对非激素依赖性恶性肿瘤，如口咽肿瘤。然而，体内和体外实验研究得出了更具争议性的结果，表明L-抗坏血酸的作用具有剂量依赖性，可能还具有时间依赖性，且根据所研究的物种或器官不同而产生不同的效果。本文讨论了将L-抗坏血酸与口腔癌及致癌作用联系起来的流行病学和实验证据的更新情况，并简要回顾了L-抗坏血酸可能的作用机制。
