分泌神经素，一种新型神经肽，存在于人类牙髓中。

Secretoneurin, a novel neuropeptide, in the human dental pulp.

作者信息

Pertl C, Kaufmann W, Amann R, Heinemann A, Ebeleseder K, Polansky R, Saria A, Kim S

机构信息

Department of Oral Surgery and Oral Radiology, Dental School, University of Graz, Austria.

出版信息

Arch Oral Biol. 1998 May;43(5):361-5. doi: 10.1016/s0003-9969(98)00016-8.

DOI:10.1016/s0003-9969(98)00016-8

PMID:9681111

Abstract

Secretoneurin is a neuropeptide that is stored in and released from primary afferent neurones. By radioimmunoassay and immunohistochemistry, secretoneurin was here demonstrated in the human dental pulp and localized in varicose nerve fibres that were frequently associated with blood vessels. No significant correlation was found between the levels of immunoreactive secretoneurin and immunoreactive calcitonin-gene related peptide. The results suggest that primary afferent neurones of the human dental pulp contain secretoneurin, which may influence local inflammatory responses if it is released together with other neuropeptides.

摘要

分泌神经素是一种储存在初级传入神经元并从其中释放的神经肽。通过放射免疫分析和免疫组织化学方法，在人牙髓中证实了分泌神经素的存在，并定位在常与血管相关的曲张神经纤维中。免疫反应性分泌神经素水平与免疫反应性降钙素基因相关肽水平之间未发现显著相关性。结果表明，人牙髓的初级传入神经元含有分泌神经素，若它与其他神经肽一起释放，可能会影响局部炎症反应。