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取代4-甲基苯并吡喃-2-酮的生化作用机制。第一部分：双氧化4-甲基香豆素作为超级抗氧化剂和自由基清除剂。

Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part I: Dioxygenated 4-methyl coumarins as superb antioxidant and radical scavenging agents.

作者信息

Raj H G, Parmar V S, Jain S C, Goel S, Malhotra S, Singh A, Olsen C E, Wengel J

机构信息

Department of Biochemistry, V.P. Chest Institute, University of Delhi, India.

出版信息

Bioorg Med Chem. 1998 Jun;6(6):833-9. doi: 10.1016/s0968-0896(98)00043-1.

DOI:10.1016/s0968-0896(98)00043-1
PMID:9681149
Abstract

Twenty-three 4-methylcoumarins bearing different functionalities have been examined for the first time for their effect on NADPH-catalysed liver-microsomal lipid peroxidation with a view to establish structure-activity relationship. Dihydroxy- and diacetoxy-4-methylcoumarins produced dramatic inhibition of lipid peroxidation. 7,8-Diacetoxy-4-methylcoumarin and 7,8-dihydroxy-4-methylcoumarin were found to possess superb antioxidant and radical scavenging activities.

摘要

首次对23种具有不同官能团的4-甲基香豆素进行了研究，考察它们对NADPH催化的肝微粒体脂质过氧化的影响，以建立构效关系。二羟基和二乙酰氧基-4-甲基香豆素对脂质过氧化有显著抑制作用。发现7,8-二乙酰氧基-4-甲基香豆素和7,8-二羟基-4-甲基香豆素具有卓越的抗氧化和自由基清除活性。

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