Lindau M, Almkvist O, Johansson S E, Wahlund L O
Karolinska Institutet, Division of Geriatric Medicine, Huddinge University Hospital, Sweden.
Dement Geriatr Cogn Disord. 1998 Jul-Aug;9(4):205-13. doi: 10.1159/000017048.
Neuropsychological differences between 14 patients with a clinical diagnosis of frontal lobe degeneration of non-Alzheimer type (FLD) and 15 patients with a clinical diagnosis of Alzheimer's disease (AD) were studied. The most efficient psychometric predictors of FLD were Digit Symbol, estimation tasks, word list recall, and particularly the FAS word fluency test. Behavioral predictors of FLD and AD showed a double dissociation: regression and impulsivity characterized FLD, whereas lack of motivation and slowness were typical of AD. Cognitive and behavioral differences between groups were not related to the degree of dementia, as measured by Mini Mental State Examination, indicating that differences remained during progression of the diseases.
对14例临床诊断为非阿尔茨海默型额叶变性（FLD）的患者和15例临床诊断为阿尔茨海默病（AD）的患者的神经心理学差异进行了研究。FLD最有效的心理测量预测指标是数字符号、估计任务、单词列表回忆，尤其是FAS单词流畅性测试。FLD和AD的行为预测指标表现出双重分离：FLD的特征是退缩和冲动，而AD的典型特征是缺乏动机和迟缓。两组之间的认知和行为差异与简易精神状态检查所测量的痴呆程度无关，这表明在疾病进展过程中差异仍然存在。
