Pace V
Novartis Crop Protection AG; Toxicology, Basle, Switzerland.
Exp Toxicol Pathol. 1998 Jun;50(3):225-8. doi: 10.1016/S0940-2993(98)80087-0.
Neoplasms of the choroid plexus are very rare in the rat, and few cases have been described. We report on a spontaneously occurring choroid plexus carcinoma arising from the fourth ventricle in a 2-year-old female albino rat. The infiltrative growth was observed in the adjacent brain parenchyma, in the wall of the vessels of the circle of Willis, in the perivascular space of VIRCHOW and ROBIN and in the leptomeninges. Immunohistochemical investigations demonstrated positive staining for cytokeratin (Lu-5) indicating that choroid plexus tumors in the rat express epithelial differentiation. The diagnosis was made on the basis of microscopical and immunohistochemical findings.
脉络丛肿瘤在大鼠中极为罕见，仅有少数病例被报道。我们报告了一例2岁雌性白化大鼠自发产生的起源于第四脑室的脉络丛癌。在邻近的脑实质、 Willis环血管壁、魏尔啸间隙和罗宾间隙的血管周围间隙以及软脑膜中均观察到浸润性生长。免疫组织化学研究显示细胞角蛋白（Lu-5）呈阳性染色，表明大鼠脉络丛肿瘤表达上皮分化。诊断基于显微镜和免疫组织化学检查结果。
