Parry R, Plowman D, Delves H T, Roberts N B, Birchall J D, Bellia J P, Davenport A, Ahmad R, Fahal I, Altmann P
Wessex Renal & Transplant Unit, St Mary's Hospital, Portsmouth, UK.
Nephrol Dial Transplant. 1998 Jul;13(7):1759-62. doi: 10.1093/ndt/13.7.1759.
Aluminium toxicity in dialysis patients is well described. Aluminium has a close chemical affinity with silicon. Silicon may have a role in protection against aluminium toxicity.
We measured serum aluminium and silicon levels from haemodialysis patients from four different centres.
Though no relationship was seen across all centres combined, in one centre there was a reciprocal relationship in patients on home haemodialysis (who did not require reverse osmosis). Median (range) aluminium levels were higher, 2.2 (0.4-9.6) micromol/l when serum silicon was less than 150 micromol/l, and lower, 1.1 (0.2-2.8) micromol/l when serum silicon levels were greater than 150 micromol/l (P = 0.03).
In patients treated by haemodialysis without reverse osmosis high serum silicon concentrations were associated with lower serum aluminium concentrations than those with low serum silicon. Further work needs to confirm a preventative role for silicon in the accumulation and subsequent toxicity of aluminium in dialysis patients.
透析患者的铝中毒已得到充分描述。铝与硅具有密切的化学亲和力。硅可能在预防铝中毒方面发挥作用。
我们测量了来自四个不同中心的血液透析患者的血清铝和硅水平。
尽管综合所有中心来看未发现相关性，但在一个中心，接受家庭血液透析（不需要反渗透）的患者中存在反比关系。当血清硅低于150微摩尔/升时，铝水平中位数（范围）较高，为2.2（0.4 - 9.6）微摩尔/升；当血清硅水平高于150微摩尔/升时，铝水平较低，为1.1（0.2 - 2.8）微摩尔/升（P = 0.03）。
在未进行反渗透的血液透析患者中，高血清硅浓度与低血清硅浓度相比，血清铝浓度较低。需要进一步开展工作来证实硅在透析患者铝蓄积及后续毒性方面的预防作用。
