Acute amiodarone-induced lung toxicity.

OBJECTIVE

To investigate any relationship between the pathological features of amiodarone-induced pulmonary toxicity (APT) and clinical use of amiodarone in patients dying from acute respiratory distress syndrome (ARDS).

DESIGN

Retrospective study. Review of clinical and pathological findings of patients dying from ARDS.

SETTING

Intensive Care Unit (ICU) and Pathology Department of University hospital.

SUBJECTS

Ten patients with clinical diagnosis of ARDS, who died in ICU and underwent post mortem examination.

INTERVENTIONS

Case note review of clinical details; independent review of histological specimens.

MEASUREMENT AND RESULTS

Over a 3-year period, ten patients underwent post mortem examination, of whom seven had received amiodarone. Three patients who received longer than 48 h of amiodarone had histological changes of widespread lipoid pneumonia, a recognised pattern of APT.

CONCLUSIONS

Acute amiodarone pulmonary toxicity is a definite pathological entity in ICU patients. High oxygen concentrations may be a risk factor, while pre-existing pathology, e. g. ARDS, may mask its development. Amiodarone should be used with caution in this group of patients.