Lange U, Teichmann J, Doppl W, Klör H
Department of Rheumatology, University of Giessen, Ludwigstr. 37-39, D-61231 Bad Nauheim, Germany.
Eur J Med Res. 1998 Jul 20;3(7):331-9.
Whipple's disease is a multisystemic infectious disease whose pathogen, a gram-unstable actinomycete, has been characterized in the meantime by molecular-biological techniques (polymerase chain reaction). This infectious disease which was firstly described in 1907 by G.H. Whipple as intestinal lipodystrophy appears rarely and sporadically and can affect nearly every organ, in the course of which the small intestine is also concerned in the majority of patients. The symptoms and signs are polymorphous and depend on organic involvement and stage. This leads to significant difficulties concerning differential diagnosis and to a delay in diagnosis. Misjudging the syndromes provokes invalidism and death whereas correct therapy leads to a cure in most of the cases.
惠普尔病是一种多系统感染性疾病，其病原体是一种革兰氏不稳定放线菌，目前已通过分子生物学技术（聚合酶链反应）进行了鉴定。这种传染病于1907年由G.H.惠普尔首次描述为肠道脂肪营养不良，发病率低且呈散发性，几乎可累及每个器官，大多数患者的小肠也会受到影响。症状和体征多种多样，取决于器官受累情况和疾病阶段。这给鉴别诊断带来了很大困难，并导致诊断延迟。误诊会导致残疾和死亡，而正确的治疗在大多数情况下可治愈疾病。
