Isaza G D, Posner J D, Altose M D, Kelsen S G, Cherniack N S
Respir Physiol. 1976 Jul;27(1):87-98. doi: 10.1016/0034-5687(76)90020-7.
The pressures generated by the inspiratory muscles as they contract isometrically during airway occlusion seem to be a measure of respiratory neuron efferent activity. The ventilatory and occlusion pressure responses to increasing levels of CO2 were studied in goats, awake and anesthetized, with and without inspiratory flow resistance. Hypercapnia was produced by rebreathing. Randomly, during rebreathing, inspiratory airflow was prevented on single breaths. Ventilation and pressures developed during the first 100, 200, 300 and 400 milliseconds of an inspiratory effort against a complete occlusion increased linearly with CO2 in both awake and anesthetized animals. Anesthesia reduced both the ventilatory and occlusion pressure responses to CO2. Inspiratory resistance increased occlusion pressure responses in awake goats but not in the same animals when anesthetized. Inspiratory airflow resistance seems to augment respiratory efferent activity as reflected in the pressure responses only in conscious goats. Thus the response to an inspiratory resistance seems to depend on the state of consciousness.
吸气肌在气道阻塞时等长收缩所产生的压力似乎是呼吸神经元传出活动的一种度量。在清醒和麻醉状态下、有或无吸气气流阻力的山羊中，研究了对逐渐增加的二氧化碳水平的通气和阻塞压力反应。通过重复呼吸产生高碳酸血症。在重复呼吸过程中，随机在单次呼吸时阻止吸气气流。在清醒和麻醉动物中，对抗完全阻塞的吸气努力的前100、200、300和400毫秒内产生的通气和压力随二氧化碳呈线性增加。麻醉降低了对二氧化碳的通气和阻塞压力反应。吸气阻力增加了清醒山羊的阻塞压力反应，但在相同动物麻醉时则没有增加。吸气气流阻力似乎仅在清醒山羊中通过压力反应反映出增强呼吸传出活动。因此，对吸气阻力的反应似乎取决于意识状态。
