Barnett T B, Rasmussen B
Acta Physiol Scand. 1979 Jan;105(1):23-32. doi: 10.1111/j.1748-1716.1979.tb06311.x.
Steady-state responses to hyperoxic hypercapnia and eucapnic hypoxia were measured both as minute ventilation (VE) and as inspiratory mouth occlusion pressure (P0.1) with and without 25 cm H2O/I/s added resistance (R). Reduction in slope of the ventilatory response to CO2 with R was highly significant in all 3 subjects whereas the response to hypoxia was barely significantly reduced in 1 subject and not significantly decreased in two. Although P0.1 was higher with than without R under all conditions, the slope of the P0.1 response to CO2 with R was not increased in two subjects and only slightly increased in the third. The slope of the P0.1 response to hypoxia was significantly greater in all subjects with R. Expiratory reserve volume was increased with R but the change was the same with hypoxia and hypercapnia. We conclude that ventilation is better maintained with resistive loading during hypoxia than during hypercapnia and that this results from a greater force output of inspiratory muscles as reflected by a higher P0.1. This suggests a greater neural output to these muscles.
在有和没有添加25 cm H₂O/I/s阻力（R）的情况下，分别以分钟通气量（VE）和吸气末口腔阻断压（P0.1）来测量对高氧性高碳酸血症和等碳酸性低氧血症的稳态反应。在所有3名受试者中，R使对二氧化碳的通气反应斜率降低非常显著，而对低氧血症的反应在1名受试者中仅略有显著降低，在另外两名受试者中则无显著降低。尽管在所有条件下有R时的P0.1均高于无R时，但在两名受试者中，有R时P0.1对二氧化碳的反应斜率并未增加，在第三名受试者中仅略有增加。在所有有R的受试者中，P0.1对低氧血症的反应斜率显著更大。呼气储备量随R增加，但低氧血症和高碳酸血症时的变化相同。我们得出结论，与高碳酸血症期间相比，低氧血症期间通过阻力负荷能更好地维持通气，这是由于吸气肌产生了更大的力量输出，表现为更高的P0.1。这表明对这些肌肉有更大的神经输出。
