Yu W, Yue G, Han X, Chen J, Tian B
China Institute of Atomic Energy, Beijing, China.
Med Phys. 1998 Jul;25(7 Pt 1):1222-4. doi: 10.1118/1.598299.
Accelerator-based neutron source have been considered to be practical for boron neutron capture therapy (BNCT). Based on experience with a parameters of the Brookhaven National Laboratory BMRR reactor neutron source, which has been used in treatment experiments, the future accelerator-based neutron source for BNCT should have the properties of low energy distribution (< 100 keV) and high flux (about 10(9) neutrons per second per square centimeter) in the patient zone. Using protons to bombard thick 7Li targets, generating neutrons via the 7Li(p,n)7Be reaction, is one of the optimal choices for this kind of neutron source. Neutron yield data versus incident energy are necessary in order to select the proper incident energy and for estimating how high the incident proton current should be. The required proton beam current intensity is one of the key parameters for an accelerator useful for BNCT. In the present work, neutron yields of the 7Li(p,n)7Be reaction with a thick lithium target and incident energies of 1.885 and 1.9 MeV were measured at 0 degree with respect to the incident beam direction. The results are (3.08 +/- 0.17) x 10(12) and (5.71 +/- 0.32) x 10(12) neutrons/C sr, respectively. Neutron yield angular distribution measurements at 2 MeV incident energy were also performed. The proton beams were generated by the Peking University 4.5 MV electrostatic accelerator. The emitted neutrons from these reactions have the advantages of low energy distribution and forward angular distribution, which are requirements for a BNCT neutron source. The data obtained in this work can be used as a reference to study the accelerator-based neutron sources for BNCT.
基于加速器的中子源已被认为对硼中子俘获疗法(BNCT)具有实用性。根据布鲁克海文国家实验室BMRR反应堆中子源(已用于治疗实验)的参数经验,未来用于BNCT的基于加速器的中子源应在患者区域具有低能分布(<100 keV)和高通量(约每秒每平方厘米10⁹个中子)的特性。使用质子轰击厚锂靶,通过⁷Li(p,n)⁷Be反应产生中子,是这种中子源的最佳选择之一。为了选择合适的入射能量以及估算入射质子电流应达到多高,需要中子产额与入射能量的数据。所需的质子束电流强度是对BNCT有用的加速器的关键参数之一。在本工作中,测量了厚锂靶在相对于入射束方向为0度时,入射能量为1.885 MeV和1.9 MeV的⁷Li(p,n)⁷Be反应的中子产额。结果分别为(3.08±0.17)×10¹²和(5.71±0.32)×10¹²个中子/(C·sr)。还进行了入射能量为2 MeV时的中子产额角分布测量。质子束由北京大学4.5 MV静电加速器产生。这些反应发射的中子具有低能分布和前向角分布的优点,这是BNCT中子源的要求。本工作获得的数据可作为研究用于BNCT的基于加速器的中子源的参考。