Nirmal S, Cherian T, Samuel B U, Rajasingh J, Raghupathy P, John T J
Department of Child Health, Christian Medical College & Hospital, Vellore, India.
Vaccine. 1998 May-Jun;16(9-10):928-31. doi: 10.1016/s0264-410x(97)00293-4.
Seventy eight infants aged 6-8 weeks received either two doses of 0.1 ml of inactivated poliovirus vaccine (IPV) intradermally 8 weeks apart (group A) or three doses 4 weeks apart (group B). Pre- and 4 weeks post-immunization serum samples were tested for the presence and titer of neutralizing antibody to poliovirus types 1, 2 and 3. The seroconversion rates to poliovirus types 1, 2 and 3 were 90, 70 and 97%, respectively, among infants in group A and 90, 80 and 98%, respectively, in group B; in children without pre-existing maternal antibody, seroconversion rates were 100% to all three poliovirus serotypes in both groups. These rates were comparable to those in children receiving five doses of OPV or two doses of intramuscular IPV. Intradermal administration of fractional doses of IPV may be a less expensive alternative for use in developing countries.
78名6至8周龄的婴儿分别接受了以下两种接种方式：A组婴儿在8周内间隔8周皮内注射两剂0.1毫升灭活脊髓灰质炎病毒疫苗（IPV）；B组婴儿在4周内间隔4周接种三剂。在免疫前和免疫后4周采集血清样本，检测针对脊髓灰质炎病毒1型、2型和3型的中和抗体的存在情况和滴度。A组婴儿中，脊髓灰质炎病毒1型、2型和3型的血清转化率分别为90%、70%和97%；B组婴儿中，相应的血清转化率分别为90%、80%和98%。在没有母源抗体的儿童中，两组对所有三种脊髓灰质炎病毒血清型的血清转化率均为100%。这些转化率与接受五剂口服脊髓灰质炎疫苗（OPV）或两剂肌肉注射IPV的儿童的转化率相当。皮内注射小剂量IPV可能是发展中国家一种成本较低的替代方法。
