Yousafzai Mohammad Tahir, Saleem Ali Faisal, Mach Ondrej, Baig Attaullah, Sutter Roland W, Zaidi Anita K M
Aga Khan University, Karachi, Pakistan.
Polio Eradication Department, World Health Organization, Geneva, Switzerland.
Heliyon. 2017 Sep 18;3(8):e00395. doi: 10.1016/j.heliyon.2017.e00395. eCollection 2017 Aug.
Administration of intradermal fractional dose of inactivated poliovirus vaccine (fIPV) has proven to be safe and immunogenic; however, its intradermal application using needle and syringe is technically difficult and requires trained personnel.
We assessed feasibility of conducting an intradermal fIPV campaign in polio high risk neighborhood of Karachi using Tropis needle-free injector. During the one-day fIPV campaign, we measured average "application time" to administer fIPV with Tropis, collected ergonomic information and measured vaccine wastage.
Eleven vaccinator teams, after two-day training, immunized 582 children between 4 months and 5 years of age. Average "application time" ranged from 35-75 seconds; the "application time" decreased with the number of children vaccinated from 68 to 38 seconds between 1st and 30th child. 10/11 (91%) vaccinator teams found no ergonomic issues; 1/11 (9%) assessed that it was not easy to remove air bubbles when filling the device. There was 0% vaccine loss reported. No adverse events following immunizations were reported.
We demonstrated that it is feasible, safe and efficient to use Tropis for the administration of fIPV in a campaign setting.
皮内注射分剂量灭活脊髓灰质炎疫苗（fIPV）已被证明是安全且具有免疫原性的；然而，使用针头和注射器进行皮内注射在技术上具有难度，且需要经过培训的人员。
我们评估了在卡拉奇脊髓灰质炎高风险社区使用Tropis无针注射器开展皮内fIPV接种活动的可行性。在为期一天的fIPV接种活动中，我们测量了使用Tropis接种fIPV的平均“接种时间”，收集了人体工程学信息，并测量了疫苗浪费情况。
11个接种团队在经过两天的培训后，为582名4个月至5岁的儿童进行了免疫接种。平均“接种时间”为35 - 75秒；“接种时间”随着接种儿童数量的增加而减少，从第1名儿童到第30名儿童，接种时间从68秒降至38秒。11个接种团队中有10个（91%）未发现人体工程学问题；1个（9%）团队评估在填充设备时不容易排出气泡。报告的疫苗损失率为0%。未报告免疫接种后的不良事件。
我们证明了在接种活动中使用Tropis进行fIPV接种是可行、安全且高效的。
