Pelletier L, Chung P, Duclos P, Manga P, Scott J
Division of Immunization, Laboratory Centre for Disease Control (LCDC), Ottawa, Canada.
Vaccine. 1998 May-Jun;16(9-10):989-96. doi: 10.1016/s0264-410x(97)00281-8.
In 1992, because of the limitations of the one-dose measles immunization program, the National Advisory Committee on Immunization (NACI) recommended a two-dose measles immunization program to eliminate measles. More recently, NACI recommended also a special catch-up program to prevent predicted measles outbreaks and to achieve an earlier elimination of measles. The objective of this study was to complete a benefit-cost analysis of a two-dose immunization program with and without a mass catch-up compaign compared with the current one-dose program. The resulting benefit: cost ratios vary between 2.61:1 and 4.31:1 depending on the strategy used and the age of the children targeted. Given the parameters established for this analysis, the benefits of a second-dose vaccination program against measles far outweight the costs of such a program under all scenarios.
1992年，由于单剂量麻疹免疫计划的局限性，国家免疫咨询委员会（NACI）建议采用两剂次麻疹免疫计划以消除麻疹。最近，NACI还建议开展一项特别的补种计划，以预防预计的麻疹疫情并更早地消除麻疹。本研究的目的是完成一项两剂次免疫计划的效益成本分析，该计划有无大规模补种活动，并与当前的单剂次计划进行比较。根据所采用的策略和目标儿童的年龄，所得的效益成本比在2.61:1至4.31:1之间。鉴于本次分析所设定的参数，在所有情况下，第二剂次麻疹疫苗接种计划的效益远远超过该计划的成本。
