Furazolidone toxicosis in female Japanese quail (Coturnix coturnix japonica): pathomorphological changes in reproductive tract and reversibility of the induced changes.

Female Japanese quail (Coturnix coturnix Japonica) placed in 3 equal groups were given 600, 400 or 0 mg furazolidone (Fz)/kg feed for 4 w and then withdrawn for another 4 w. Another (pair-fed) group of same size was given basal feed as much as was consumed by the quail fed 600 mg Fz/kg feed. Fz feeding decreased body weight, feed intake and egg production. Ovaries of the Fz-fed quail decreased in weight and size and were studded with small follicles. Magnum, isthmus and uterus in Fz-fed groups had decreased area, height and number of mucosal folds compared with the control group. Microscopically, in Fz-fed groups, the mucosal glands in magnum and isthmus had decreased cell height with centrally located nuclei and foamy cytoplasm. In the 600 mg Fz-fed group, some birds had atrophy of the glandular tissue in the mucosa and infiltration of mononuclear cells and fibroblasts. Upon cessation of the Fz feeding, all parameters reversed gradually and became non-significantly different from control quail. These observations suggested that Fz-induced changes in mature female quail were reversible.