Siddique M, Khan M Z, Muhammad G, Islam N
Department of Veterinary Pathology, University of Agriculture, Faisalabad, Pakistan.
Vet Hum Toxicol. 1996 Dec;38(6):413-7.
Furazolidone (Fz) was fed to 4 groups of cockerels 15 w of age at 0, 400, 800 and 1200 mg/kg feed for 3 w and then was withdrawn for another 3 w. In a second experiment conducted simultaneously cockerels were fed these same Fz levels for 6 w and then were withdrawn from Fz feed for 4 w. In both experiments, 800 and 1200 mg Fz/kg feed resulted in decreases in comb and wattle size and in the weight of testes. The testes had smaller seminiferous tubule diameters and increased relative and decreased absolute volumes of interstitium. Spermatogenesis was not observed in cockerels fed 800 and 1200 mg Fz/kg feed. Withdrawal of Fz resulted in increased comb and wattle size, weight of testes and diameter of the seminiferous tubules. There was also an increase in absolute volume of interstitium along with decreased relative interstitium volume. Spermatogenesis was restored.
将呋喃唑酮（Fz）以0、400、800和1200毫克/千克饲料的剂量投喂给4组15周龄的公鸡，持续3周，然后停喂3周。在同时进行的第二项实验中，公鸡以相同的Fz水平投喂6周，然后停喂含Fz的饲料4周。在两项实验中，800和1200毫克Fz/千克饲料均导致鸡冠和肉垂大小以及睾丸重量下降。睾丸的生精小管直径变小，间质的相对体积增加而绝对体积减小。在投喂800和1200毫克Fz/千克饲料的公鸡中未观察到精子发生。停止投喂Fz后，鸡冠和肉垂大小、睾丸重量以及生精小管直径增加。间质的绝对体积也增加，同时间质相对体积减小。精子发生得以恢复。
