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[电离辐射与硝基化合物对谷氨酸代谢碱性酶活性的联合作用]

[The combined action of ionizing radiation and nitro compounds on the activity of the basic enzymes of glutamic acid metabolism].

作者信息

Zyrianova T N, Lavrova V M

机构信息

Byelorussian State University, Minsk.

出版信息

Radiats Biol Radioecol. 1998 May-Jun;38(3):405-10.

PMID:9682735
Abstract

The activity of aspartate aminotransferase, glutamate dehydrogenase in the liver of rats in 1, 7 and 15 days after gamma irradiation effect of the dose of 0.5 Gy on the background of consumption by animals of sodium nitrate, sodium nitrite and nitrosodiethylamine was studied. The combined influence of chemical agents and gamma irradiation modified the effects of nitro compounds-xenobiotics on processes of the synthesis and dissociation of the glutamic acid as well as the intensity of transamination of the reamination by aspartate aminotransferase.

摘要

研究了在给予大鼠0.5 Gy剂量γ射线照射后1天、7天和15天,在动物摄入硝酸钠、亚硝酸钠和亚硝基二乙胺的背景下,大鼠肝脏中天冬氨酸转氨酶、谷氨酸脱氢酶的活性。化学试剂与γ射线的联合作用改变了硝基化合物(外源性物质)对谷氨酸合成与解离过程以及天冬氨酸转氨酶转氨再氨基化强度的影响。

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