[暴露于电离辐射慢性作用下的受试者中糖蛋白A基因座突变水平的估计]

[The estimation of the level of mutations at the glycophorin A locus in subjects exposed to the chronic action of ionizing radiation].

作者信息

Rozhdestvenskiĭ L M, Okladnikova N D, Smirnova T N, Tel'nov V I, Pleshanov P G, Kato P, Langlois R G

机构信息

State Research Center of Russia, Institute of Biophysics, Moscow.

出版信息

Radiats Biol Radioecol. 1998 May-Jun;38(3):443-50.

PMID:9682741

Abstract

11 persons, who had been irradiated chronically at low dose rate under occupational conditions in 1950s in doses 220-581 cGy according data of individual film dosimeters, and 5 control persons were examined regarding the level of glycophorin A (GPA) mutation type NO and NN in blood erythrocytes. Significantly higher level of GPA mutations type NO was registered in average in the group of exposed persons (23.2 +/- 4.6 x 10(-6)) compared with the control group (10.2 +/- 2.1 x 10(-6)) through the dose dependence was expressed slightly. The coefficient of the linear regression has equaled (2.3 +/- 1.2 x 10(-6)) Gy. The outlook on GPA assay usage in retrospective biodosimetry is discussed.

摘要

根据个人胶片剂量计的数据，对1950年代在职业条件下受到低剂量率慢性照射、剂量为220 - 581 cGy的11人，以及5名对照人员进行了血红细胞中血型糖蛋白A（GPA）突变类型NO和NN水平的检测。与对照组（10.2±2.1×10⁻⁶）相比，受照人群组中GPA突变类型NO的平均水平显著更高（23.2±4.6×10⁻⁶），尽管剂量依赖性表现得较为微弱。线性回归系数为（2.3±1.2×10⁻⁶）Gy。讨论了GPA检测在回顾性生物剂量测定中的应用前景。