Ueta E, Osaki T, Yamamoto T, Yoneda K
Department of Oral Surgery, Kochi Medical School, Japan.
Oral Oncol. 1998 Mar;34(2):105-11. doi: 10.1016/s1368-8375(97)00063-8.
The successful treatment results of a case of maxillary adenoid cystic carcinoma (ACC) and the possibility of differentiation of ACC cells with chemoradioimmunotherapy are described. Combined therapy was applied to two maxillary ACCs. Adoptive immunotherapy consisted of intra-arterial injection of lymphokine-activated killer cells (total 9.0 x 10(8) cells) and recombinant interleukin-2 (1.8 x 10(5) U) and interferon-gamma (1.8 x 10(5) U) was combined with 60Co radiation (50 Gy), 5-fluorouracil (4000 mg) and peplomycin (10 mg). Immunohistochemical staining of the biopsy material obtained during the therapy revealed a marked decrease of proliferating cell nuclear antigen-positive cells and a prominent increase of Lewis Y antigen- and bone morphogenetic protein-2-positive cells. The disappearance of tumour cells and the remodeling of the sinus wall with calcification in the sinus cavity, which had been occupied by the tumour, were observed after therapy in both patients. Adoptive immunotherapy in combination with chemoradiotherapy is useful for the treatment of ACC.
本文描述了一例上颌腺样囊性癌（ACC）的成功治疗结果以及通过放化疗免疫疗法使ACC细胞分化的可能性。联合疗法应用于两例上颌ACC。过继性免疫疗法包括动脉内注射淋巴因子激活的杀伤细胞（共9.0×10⁸个细胞）、重组白细胞介素-2（1.8×10⁵U）和干扰素-γ（1.8×10⁵U），并联合60Co放疗（50Gy）、5-氟尿嘧啶（4000mg）和培普利霉素（10mg）。治疗期间获取的活检材料的免疫组织化学染色显示增殖细胞核抗原阳性细胞显著减少，而Lewis Y抗原和骨形态发生蛋白-2阳性细胞显著增加。治疗后在两名患者中均观察到肿瘤细胞消失以及鼻窦壁重塑，鼻窦腔内曾被肿瘤占据的部位出现钙化。过继性免疫疗法联合放化疗对ACC治疗有效。
