Crawford F, Fallin D, Suo Z, Abdullah L, Gold M, Gauntlett A, Duara R, Mullan M
Roskamp Laboratories, University of South Florida, Tampa 33613, USA.
Neurosci Lett. 1998 Jun 19;249(2-3):115-8. doi: 10.1016/s0304-3940(98)00423-6.
The K variant of the butyrylcholinesterase gene (BChE) was recently found to occur at an increased frequency in a late onset Alzheimer's disease (AD) population, specifically in individuals carrying the epsilon4 allele of the apolipoprotein E (APOE) gene. This suggested synergy between these two genes resulting in an increased risk of late-onset AD. We have genotyped 62 community-based and 329 clinic-based AD cases, and 201 community-based controls at BChE and APOE and find no independent association between BChE and AD nor interaction with APOE in risk for AD in either our clinic or community-based samples.
最近发现，丁酰胆碱酯酶基因（BChE）的K变体在晚发性阿尔茨海默病（AD）人群中出现的频率增加，特别是在携带载脂蛋白E（APOE）基因ε4等位基因的个体中。这表明这两个基因之间存在协同作用，导致晚发性AD风险增加。我们对62例社区AD病例、329例临床AD病例以及201例社区对照进行了BChE和APOE基因分型，发现在我们的临床样本或社区样本中，BChE与AD之间不存在独立关联，在AD风险方面也不存在与APOE的相互作用。
