Deschênes M C, Coupland S G, Ross S A, Fick G H
Visual Electrodiagnostic Research Unit, University of Calgary, Alberta, Canada.
Doc Ophthalmol. 1997;94(3):223-37. doi: 10.1007/BF02582981.
The focal electroretinogram, which measures the functional integrity of the distal retina of the macula, was recorded with a hand-held stimulator-ophthalmoscope in 26 eyes from patients with non-insulin-dependent diabetes mellitus with normal fundus photography, and in 52 control eyes of similar age range. Implicit time and amplitude of the responses were studied as a function of the age, glycemic control through glycosylated hemoglobin measurement and duration of diabetes. Implicit time and amplitude were significantly delayed (F=5.05, p=0.028) and reduced (F=11.26, p=0.013) in diabetic patients without diabetic retinopathy compared to control subjects. Moreover, there was a significant relationship between the implicit time (r=0.57, p=0.002) and amplitude (r=-0.65, p=0.0004) with the duration of diabetes but not with hemoglobin Alc. These results strongly suggest an early macular dysfunction in non-insulin-dependent diabetes mellitus before the appearance of diabetic retinopathy.
使用手持刺激器检眼镜记录了26只来自眼底照相正常的非胰岛素依赖型糖尿病患者眼睛以及52只年龄范围相似的对照眼睛的黄斑区视网膜电图，该检查用于测量黄斑区远端视网膜的功能完整性。研究了反应的潜伏时间和振幅与年龄、通过糖化血红蛋白测量的血糖控制情况以及糖尿病病程之间的关系。与对照受试者相比，无糖尿病视网膜病变的糖尿病患者的潜伏时间和振幅明显延迟（F = 5.05，p = 0.028）和降低（F = 11.26，p = 0.013）。此外，潜伏时间（r = 0.57，p = 0.002）和振幅（r = -0.65，p = 0.0004）与糖尿病病程之间存在显著关系，但与糖化血红蛋白Alc无关。这些结果强烈表明，在糖尿病视网膜病变出现之前，非胰岛素依赖型糖尿病患者就已存在早期黄斑功能障碍。
