Lominadze D, Joshua I G, Schuschke D A
Center for Applied Microcirculatory Research and Department of Physiology and Biophysics, University of Louisville, Kentucky 40292, USA.
Am J Hypertens. 1998 Jul;11(7):784-9. doi: 10.1016/s0895-7061(98)00056-9.
Alterations of red blood cell (RBC) aggregation and plasma viscosity are major contributors to the changes in blood rheologic properties that cause an increase in peripheral vascular resistance during the development of hypertension. Although basic research and clinical study have provided considerable understanding of the pathophysiology of hypertension, the objective of this study was to determine whether an increase in RBC aggregability and plasma viscosity precede or accompany the development of high arterial blood pressure. To address this question, RBC aggregation and plasma viscosity were studied in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) at 3 and 12 weeks of age. The plasma concentrations of fibrinogen and fibronectin (FN) were also analyzed in both age groups. RBC aggregability and plasma viscosity were increased in both young and mature SHR compared to age-matched normotensive WKY rats. Mean arterial blood pressure and diastolic pressures were increased in mature hypertensive rats, whereas in young SHR only diastolic pressure was elevated significantly. The concentration of fibrinogen was higher only in the mature hypertensive rats, whereas plasma FN content was greater in both 3- and 12-week-old SHR compared to age-matched WKY. These results show the existence of increased RBC aggregability and plasma hyperviscosity not only during the established phase of hypertension, but also during the early stage of hypertension development, when mean arterial blood pressure is not yet significantly elevated in the genetically hypertensive rat model. These changes may be related to significant increase in the plasma protein FN, which occurs at the same time as the RBC aggregability and plasma viscosity changes. These results may increase attention to changes in the rheologic properties and to the mechanisms involved in these processes in the early stages of hypertension development.
红细胞（RBC）聚集性和血浆黏度的改变是导致高血压发展过程中外周血管阻力增加的血液流变学特性变化的主要因素。尽管基础研究和临床研究已经对高血压的病理生理学有了相当的了解，但本研究的目的是确定红细胞聚集性增加和血浆黏度增加是先于还是伴随高动脉血压的发展。为了解决这个问题，在3周龄和12周龄的自发性高血压大鼠（SHR）和正常血压的Wistar-Kyoto大鼠（WKY）中研究了红细胞聚集性和血浆黏度。还分析了两个年龄组的血浆纤维蛋白原和纤连蛋白（FN）浓度。与年龄匹配的正常血压WKY大鼠相比，年轻和成熟的SHR的红细胞聚集性和血浆黏度均增加。成熟高血压大鼠的平均动脉血压和舒张压升高，而年轻SHR中只有舒张压显著升高。纤维蛋白原浓度仅在成熟高血压大鼠中较高，而与年龄匹配的WKY相比，3周龄和12周龄的SHR的血浆FN含量均更高。这些结果表明，不仅在高血压的既定阶段，而且在高血压发展的早期阶段，即基因高血压大鼠模型中平均动脉血压尚未显著升高时，红细胞聚集性增加和血浆高黏滞性就已存在。这些变化可能与血浆蛋白FN的显著增加有关，血浆蛋白FN的增加与红细胞聚集性和血浆黏度的变化同时发生。这些结果可能会增加对高血压发展早期血液流变学特性变化及其相关机制的关注。
