Chabanel A, Schachter D, Chien S
Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
Hypertension. 1987 Dec;10(6):603-7. doi: 10.1161/01.hyp.10.6.603.
The micropipette test was used to study the effects of age on the elasticity of red blood cell (RBC) membrane in spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY), ranging from 3 to 23 weeks of age. The development of hypertension in the SHR started at 3 weeks and was fully established at 7 to 8 weeks. In the developmental phase of hypertension (3-5 weeks), the SHR showed a significant increase in RBC membrane elastic modulus (i.e., a decrease in RBC membrane deformability) when compared with the age-matched normotensive control rats (WKY). After the establishment of hypertension (7-8 weeks), however, the deformability of the RBC membrane of SHR improved and became comparable to that of the WKY. These results indicate that abnormal erythrocyte membrane elasticity is an early event in SHR and that adaptive recovery occurs when hypertension is fully developed.
采用微量移液器试验研究年龄对自发性高血压大鼠（SHR）和年龄匹配的正常血压Wistar-Kyoto大鼠（WKY）红细胞（RBC）膜弹性的影响，年龄范围为3至23周。SHR的高血压在3周龄时开始出现，并在7至8周龄时完全形成。在高血压发展阶段（3至5周），与年龄匹配的正常血压对照大鼠（WKY）相比，SHR的红细胞膜弹性模量显著增加（即红细胞膜变形性降低）。然而，在高血压形成后（7至8周），SHR的红细胞膜变形性有所改善，与WKY相当。这些结果表明，红细胞膜弹性异常是SHR的早期事件，并且在高血压完全发展时会发生适应性恢复。
