Marre M
Centre Hospitalier Universitaire, Angers, France.
Am J Hypertens. 1998 Jul;11(7):884-6. doi: 10.1016/s0895-7061(98)00077-6.
Microalbuminuria, a slightly elevated urinary albumin excretion, predicts renal failure in insulin-dependent diabetic patients and premature cardiovascular mortality in non-insulin-dependent diabetic patients and in the general population. It can be related to all currently established cardiovascular risk factors. Regarding the relationship between urinary albumin and blood pressure, microalbuminuria seems to be an early indicator of renal disease, causing high blood pressure in some instances, whereas it looks like the consequences of renal damage produced by severe hypertension in other instances. To establish whether microalbuminuria is an integrated risk marker for renal and cardiovascular events, or truly a risk factor, and to validate the usefulness of some peculiar treatment strategies, clinical trials are required, taking microalbuminuria as a selection criteria, and renal and cardiovascular events as endpoints.
微量白蛋白尿，即尿白蛋白排泄轻度升高，可预测胰岛素依赖型糖尿病患者的肾衰竭以及非胰岛素依赖型糖尿病患者和普通人群的心血管疾病过早死亡率。它可能与所有目前已确定的心血管危险因素有关。关于尿白蛋白与血压之间的关系，微量白蛋白尿似乎是肾脏疾病的早期指标，在某些情况下会导致高血压，而在其他情况下它似乎是严重高血压所致肾脏损害的后果。为了确定微量白蛋白尿是肾脏和心血管事件的综合风险标志物，还是真正的危险因素，并验证某些特殊治疗策略的有效性，需要进行以微量白蛋白尿为选择标准、以肾脏和心血管事件为终点的临床试验。
