Kwon Y H, Park H J, Jap A, Ugurlu S, Caprioli J
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA.
Am J Ophthalmol. 1998 Jul;126(1):29-36. doi: 10.1016/s0002-9394(98)00062-2.
To compare long-term fluctuation of blue-on-yellow automated perimetry with white-on-white automated perimetry in normal subjects.
White-on-white and blue-on-yellow automated perimetry were performed on a Humphrey Visual Field Analyzer and an Octopus perimeter, both modified for blue-on-yellow perimetry. The study sample consisted of 31 eyes of 31 normal subjects for the Humphrey perimeter and 33 eyes of 33 normal subjects for the Octopus perimeter. After one practice session, each subject completed four testing sessions over a period of 2 to 8 weeks, each separated by at least 1 day. Each testing session consisted of both white-on-white and blue-on-yellow perimetry performed on one eye; the order of the tests was alternated for successive sessions. Long-term fluctuation (expressed as statistical variance) was calculated for each test location. Intersubject variability (expressed as statistical variance) across all subjects was determined for each test location.
On the Humphrey perimeter, the long term fluctuation for blue-on-yellow perimetry (4.07 +/- 3.07 dB2) was significantly greater than that for white-on-white perimetry (1.97 +/- 0.99 dB2; P < .001). Long-term fluctuation increased as a function of eccentricity for both blue-on-yellow and white-on-white perimetry. Short-term fluctuation was significantly greater for blue-on-yellow (0.46 +/- 0.25 dB) than that for white-on-white perimetry (0.29 +/- 0.19 dB; P < .02). Finally, the intersubject variability was significantly greater in blue-on-yellow (13.2 +/- 2.8 dB2) than it was in white-on-white perimetry (4.25 +/- 1.13 dB2; P < .001). Similar results were found with the Octopus perimeter.
Long-term fluctuation and short-term fluctuation of blue-on-yellow perimetry are greater than those of white-on-white perimetry in normal subjects. The increased long-term fluctuation requires appropriate statistical approaches when evaluating serial change of blue-on-yellow perimetry.
比较正常受试者蓝黄自动化视野检查与白对白自动化视野检查的长期波动情况。
在经蓝黄视野检查改良的Humphrey视野分析仪和Octopus视野计上进行白对白和蓝黄自动化视野检查。研究样本包括使用Humphrey视野计的31名正常受试者的31只眼，以及使用Octopus视野计的33名正常受试者的33只眼。经过一次练习后，每位受试者在2至8周内完成四个测试阶段，每个阶段间隔至少1天。每个测试阶段包括对一只眼进行白对白和蓝黄视野检查；连续阶段的测试顺序交替。计算每个测试位点的长期波动（以统计方差表示）。确定每个测试位点所有受试者间的变异性（以统计方差表示）。
在Humphrey视野计上，蓝黄视野检查的长期波动（4.07±3.07dB²）显著大于白对白视野检查（1.97±0.99dB²；P<.001）。蓝黄和白对白视野检查的长期波动均随偏心度增加而增加。蓝黄视野检查的短期波动（0.46±0.25dB）显著大于白对白视野检查（0.29±0.19dB；P<.02）。最后，蓝黄视野检查的受试者间变异性（13.2±2.8dB²）显著大于白对白视野检查（4.25±1.13dB²；P<.001）。使用Octopus视野计也发现了类似结果。
正常受试者中，蓝黄视野检查的长期波动和短期波动均大于白对白视野检查。在评估蓝黄视野检查的系列变化时，长期波动增加需要采用适当的统计方法。
