Clark L D, Clark R K, Heber-Katz E
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, 19104, USA.
Clin Immunol Immunopathol. 1998 Jul;88(1):35-45. doi: 10.1006/clin.1998.4519.
Regeneration is generally considered to be a phenomenon restricted to amphibians in which amputated limbs reform and regrow. We have recently noted a strain of mouse, the MRL, which displays a remarkable capacity for cartilagenous wound closure and provides an example of a phenomenon previously considered to be a form of regeneration. Specifically, through-and-through ear punches rapidly attain full closure with normal tissue architecture reminiscent of regeneration seen in amphibians as opposed to scarring, as usually seen in mammals. Histologically, we have demonstrated normal cell growth and microanatomy, including angiogenesis and chondrogenesis, as opposed to control C57BL/6 mice which have ear holes that contract minimally but do not close. Finally, this phenomenon is a genetically definable quantitative trait.
再生通常被认为是两栖动物特有的一种现象，即被截断的肢体能够重新形成并生长。我们最近注意到一种小鼠品系，即MRL小鼠，它表现出显著的软骨伤口闭合能力，为一种以前被认为是再生形式的现象提供了一个例子。具体而言，通过耳穿孔，伤口能迅速完全闭合，形成具有正常组织结构的组织，这让人联想到两栖动物的再生，而不是像哺乳动物通常那样形成疤痕。从组织学上看，我们已经证明了正常的细胞生长和微观解剖结构，包括血管生成和软骨生成，而对照的C57BL/6小鼠的耳洞虽然收缩极小但不会闭合。最后，这种现象是一种可通过基因定义的数量性状。
